Hydrochloric Acid → HCID 20484156, compound

HRID 648018Notes

Reaction equation

HRID 648018 reaction equation
[C:1]1([CH3:21])[CH:6]=[CH:5][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH2:16][CH:17]([C:18]([OH:20])=[O:19])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:3][CH:2]=1.Cl>C(O)CC(C)C>[C:1]1([CH3:21])[CH:2]=[CH:3][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH2:16][CH:17]([C:18]([O:20][CH2:3][CH2:2][CH:1]([CH3:21])[CH3:6])=[O:19])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13487077HCID 13487077, compound

Product 1

HCID 20484156HCID 20484156, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A solution of 283 mg. of 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylic acid in 20 ml. of isoamyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue purified by chromatography on alumina, to yield isoamyl 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate.

Workup

  1. distillationthe excess alcohol is distilled off in vacuo
  2. customthe residue purified by chromatography on alumina

Sources & evidence

ORD record
ord-cbe3219504104f468cd47c1fe510a77c
Source dataset
uspto-grants-1983_10
Patent number
US04410534

Reaction notes

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