Chloroform → HCID 20484710, compound

HRID 648078Notes

Reaction equation

HRID 648078 reaction equation
[CH:1]1([S:7]Cl)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:9]1([NH:15][S:16]([C:19]2[S:20][C:21]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:22]=3[N:23]=2)(=[O:18])=[O:17])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.C(N(CC)CC)C.C(Cl)(Cl)Cl>CN(C)C=O>[CH:1]1([S:7][N:15]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[S:16]([C:19]2[S:20][C:21]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:22]=3[N:23]=2)(=[O:17])=[O:18])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 6212ChloroformHCID 8471TriethylamineHCID 87312Cyclohexanesulfenyl chlorideHCID 20484714HCID 20484714, compound

Product 1

HCID 20484710HCID 20484710, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.6 grams of cyclohexyl chlorosulfide (0.0172 mole) prepared as in Example 1 is added slowly to a stirred solution containing 5.4 grams (0.0163 mole) of N-cyclohexyl-5-chlorobenzothiazole-2-sulfonamide, and 2 grams of triethylamine (0.0178 mole) in 150 ml anhydrous dimethylformamide. The temperature is maintained between about 15° and 20° C. After stirring, 100 ml of chloroform is added and the reaction mixture is poured into 2 liters of ice water, and treated as in Example 5.

Workup

  1. additionis added slowly to a stirred solution
  2. temperatureThe temperature is maintained between about 15° and 20° C
  3. additiontreated as in Example 5

Sources & evidence

ORD record
ord-67e97946bb7c4a43908e3e7d4622ff84
Source dataset
uspto-grants-1983_10
Patent number
US04410704

Reaction notes

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