Epichlorohydrin → HCID 12784476, compound

HRID 648235Notes

Reaction equation

HRID 648235 reaction equation
[CH3:1][C:2]1([CH3:15])[CH2:8][CH2:7][C:6]2=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=[C:5]2[CH2:4][C:3]1=[O:14].[CH2:16]([CH:18]1[O:20][CH2:19]1)[Cl:17]>N1CCCCC1>[Cl:17][CH2:16][CH:18]([OH:20])[CH2:19][O:13][C:9]1[C:6]2[CH2:7][CH2:8][C:2]([CH3:15])([CH3:1])[C:3](=[O:14])[CH2:4][C:5]=2[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7835EpichlorohydrinHCID 12784475HCID 12784475, compound

Product 1

HCID 12784476HCID 12784476, compound

Reagents, catalysts & solvents 1

HCID 8082PiperidineCatalyst

Procedure

Two drops of piperidine are added to 1.8 g 6,7,8,9-tetrahydro-7,7-dimethyl-6-oxo-5H-benzocyclohepten-1-ol in 8 ml epichlorohydrin. The mixture is stirred at 100° for 4 hours. The solution is evaporated, taken up in ether, filtered and concentrated to give crude 1-(3-chloro-2-hydroxypropoxy)-6,7,8,9-tetrahydro-7,7-dimethyl-5H-benzocyclohepten-6-one.

Workup

  1. customThe solution is evaporated
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-ef0a1fb9c9014169b13b8348ae0d4bd6
Source dataset
uspto-grants-1983_10
Patent number
US04411913

Reaction notes

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