反应详情

3-(4-Hydroxyphenyl)propionic acid (2.49 g, 15 mmol) was reacted with glycine ethyl ester hydrochloride in the presence of CDI and Et3N as described in Example 35 Part A. After removal of the solvent the residue was dissolved in CHCl3 and washed with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution. After drying (MgSO4) and removal of the solvent in vacuo crude title ester remained (2.44 g) as a viscous oil. NMR indicated this contained a major impurity but it was used without further purification.

1. customAfter removal of the solvent the residue
2. dissolutionwas dissolved in CHCl3
3. washwashed with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution
4. customAfter drying
5. custom(MgSO4) and removal of the solvent in vacuo crude title ester
6. customwas used without further purification