Sodium Hydroxide → HCID 20145110, compound

HRID 648630Notes

Reaction equation

HRID 648630 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH:13]([CH:15]([C:24]([NH2:26])=[O:25])[C:16]2[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=2)[CH3:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-:27].[Na+]>[Ag]=O>[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH:13]([CH:15]([C:24]([NH2:26])=[O:25])[C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:27])=[O:21])=[CH:22][CH:23]=2)[CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20145227HCID 20145227, compound

Product 1

HCID 20145110HCID 20145110, compound

Reagents, catalysts & solvents 1

HCID 92152Silver(II) oxideCatalyst

Procedure

The above compound was prepared from 4-[(1-(2-piperidinophenyl)-ethyl)-aminocarbonylmethyl]-benzaldehyde by heating with silver oxide in the presence of 1N sodium hydroxide solution for 20 minutes in a steam bath, subsequent acidification with 2N sulfuric acid at a pH of 5, extraction with ethyl acetate, and purification by column chromatography on silica gel (toluene/acetone=1:1).

Workup

  1. extractionsubsequent acidification with 2N sulfuric acid at a pH of 5, extraction
  2. customwith ethyl acetate, and purification by column chromatography on silica gel (toluene/acetone=1:1)

Sources & evidence

ORD record
ord-4c6d13faa57d42f8bb948ff0e46716dd
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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