反应详情

A mixture of 7 g of the product of Step B, 50 ml of tetrahydrofuran and 2.92 g of 4-dimethylamino-pyridine was refluxed for 24 hours and was cooled to room temperature and iced and vacuum filtered. The product was washed with tetrahydrofuran and dried under reduced pressure at 90° C. The product was stirred with 100 ml of water at room temperature and was vacuum filtered. The product was washed with water and dried under reduced pressure at 90° C. to obtain 3.5 g of 1,3-dihydro-3-methyl-1-(2-thiazolylimino)-furo[3,4-b]quinoline-9-ol melting at >270° C.

1. temperaturewas refluxed for 24 hours
2. filtrationiced and vacuum filtered
3. washThe product was washed with tetrahydrofuran
4. customdried under reduced pressure at 90° C
5. filtrationfiltered
6. washThe product was washed with water
7. customdried under reduced pressure at 90° C.