Tetrahydrofuran → HCID 178438187, compound

HRID 648746Notes

Reaction equation

HRID 648746 reaction equation
Cl[CH:2]([CH3:24])[C:3]([NH:5][C:6]1[C:11]([F:12])=[CH:10][CH:9]=[CH:8][C:7]=1[C:13](=[O:23])[CH2:14][C:15]([NH:17][C:18]1[S:19][CH:20]=[CH:21][N:22]=1)=[O:16])=O.O1CCC[CH2:26]1>CN(C)C1C=CN=CC=1>[CH2:24]([CH:2]1[C:3]2=[N:5][C:6]3[C:11]([F:12])=[CH:10][CH:9]=[CH:8][C:7]=3[C:13]([OH:23])=[C:14]2[C:15](=[N:17][C:18]2[S:19][CH:20]=[CH:21][N:22]=2)[O:16]1)[CH3:26]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 134230862-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide

Product 1

HCID 178438187HCID 178438187, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Using the procedure of Step B of Example 6, 8.5 g of the product of Step E in 85 ml of tetrahydrofuran and 3.37 g of 4-dimethylamino-pyridine were reacted to obtain 6.5 g of 1,3-dihydro-3-ethyl-1-[(2-thiazolyl)-imino]-5-fluoro-furo[3,4-b]quinoline-9-ol melting towards 210° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-e9486b9891084ef8be9336d01107d9ca
Source dataset
uspto-grants-1988_04
Patent number
US04736033

Reaction notes

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