反应详情

While cooling with ice, a solution of 3,4-dimethoxyphenylacetic acid chloride (485.2 g) in methylene chloride (1.1 liters) is added dropwise at 15°-20° C. to a solution of aminoacetaldehyde dimethylacetal (246.2 ml) and triethylamine (315 ml) in methylene chloride (2.2 liters) and the resulting mixture is stirred for 1 hour at 16°-18° C. It is then extracted several times with water, dried over magnesium sulphate and concentrated by evaporation. The resulting oil slowly crystallizes out.

1. temperatureWhile cooling with ice
2. extractionIt is then extracted several times with water
3. dry with materialdried over magnesium sulphate
4. concentrationconcentrated by evaporation
5. customThe resulting oil slowly crystallizes out