反应详情

A mixture of 2 g of 3-bromo-7-methylbenzo[b]thiophene, 4.8 g of CF3COONa, 3 g CuI and 20 ml of 1-methylpyrrolidone are vigorously stirred and heated at 160°. After a short while evolution of gas commences. Stirring is continued for one hour at 160° and a further hour at 180°. After cooling the reaction mixture is poured into water, extracted with ether/hexane (1/1) and the organic phase washed, dried and concentrated under vacuum. The raw product is chromatographed over silica gel (eluant: n-hexane) and the title compound obtained as a colourless oil.

1. temperatureheated at 160°
2. stirringStirring
3. temperatureAfter cooling the reaction mixture
4. extractionextracted with ether/hexane (1/1)
5. washthe organic phase washed
6. customdried
7. concentrationconcentrated under vacuum
8. customThe raw product is chromatographed over silica gel (eluant: n-hexane)