反应详情

A solution of 1.23 g of Part F cyano-alcohol (7.36 mmole) in 20 ml of dry methylene chloride was treated with 800 ml of dihydropyran (8.89 mmole) and catalytic amount of p-toluene sulfonic acid at 0°-5° C. After 4 hours, the reaction mixture was diluted with ether and washed with aqueous sodium bicarbonate solution. The aqueous layer was reextracted twice with ether. The combined organic extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude residue was chromatographed on a silica gel column and eluted with 2 ethyl acetate in hexane to obtain 1.61 g of title tetrahydropyranyl ether.

1. washwashed with aqueous sodium bicarbonate solution
2. extractionThe combined organic extract
3. dry with materialwas dried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe crude residue was chromatographed on a silica gel column
6. washeluted with 2 ethyl acetate in hexane