反应详情

To a mixture of potassium salt of 2-mercaptobenzimidazole (1.45 g), potassium carbonate (1.0 g) and dimethylformamide (10 ml) was added dropwise with stirring a solution of 2-bromomethyl-3,4-dimethoxypyridine (1.18 g) in dimethylformamide (2 ml), and the mixture was stirred at room temperature for 30 minutes, to which chloroform (100 ml) was added. The reaction mixture was washed with water, 1N-sodium hydroxide and water in this order, dried (with sodium sulfate) and evaporated. The residue was purified by column chromatography on silica gel (chloroform-methanol (50:1)), to give 2-[(3,4-dimethoxypyrid-2-yl)methylthio]benzimidazole (1.08 g) as a light yellow oil.

1. additionwas added dropwise
2. additionwas added
3. washThe reaction mixture was washed with water, 1N-sodium hydroxide and water in this order
4. dry with materialdried (with sodium sulfate)
5. customevaporated
6. customThe residue was purified by column chromatography on silica gel (chloroform-methanol (50:1))