反应详情

In 50 ml of isopropanol was dissolved 9.3 g of DL-2-benzyloxycarbonylamino-N5 -methyl-N1,N1 -di(n-propyl)pentane-1,5-diamide, after which 2.2 ml of conc. hydrochloric acid and 0.5 g of 10% palladium-carbon were added and catalytic reduction was carried out at room temperature under atmospheric pressure. After completion of the reaction, the palladium-carbon was removed by filtration and the solvent was removed by distillation under reduced pressure to obtain 6.7 g (yield 97%) of DL-2-amino-N5 -methyl-N1,N1 -di(n-propyl)-pentane-1,5-diamide hydrochloride having a melting point of 125°-127° C.

1. customwas carried out at room temperature under atmospheric pressure
2. customAfter completion of the reaction
3. customthe palladium-carbon was removed by filtration
4. customthe solvent was removed by distillation under reduced pressure