Chloroform → 3,6-Dichloro-2-(dichloromethyl)pyridine

HRID 649287노트

반응식

HRID 649287 반응식
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([Cl:9])[N:3]=1.[CH:10](Cl)([Cl:12])[Cl:11].[OH-].[Na+]>CN1CCCC1=O>[Cl:8][C:7]1[C:2]([CH:10]([Cl:12])[Cl:11])=[N:3][C:4]([Cl:9])=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 230162,3,6-Trichloropyridine

생성물 1

HCID 141005393,6-Dichloro-2-(dichloromethyl)pyridine

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

2,3,6-Trichloropyridine (1.0 g, 0.0055 mole) was combined with 4 g N-methylpyrrolidone, 4 g (0.033 mole) of chloroform, and 1.0 g of 50 percent aqueous sodium hydroxide (0.013 mole). The resulting mixture was stirred and warmed mildly for about 1 hour at which time the product was found to be present in the reaction mixture by gas chromatography and mass spectrometry using an authentic sample of the product as a standard. After standing overnight at ambient temperature the title compound represented about 1.7 percent of the pyridines in the mixture.

후처리

  1. temperaturewarmed mildly for about 1 hour at which time the product

출처 및 근거

ORD 기록
ord-cf5615007f874751a6cc3524fcd7feb8
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04739070

반응 노트

불러오는 중…