Hydrochloric Acid → HCID 20143507, compound

HRID 649296Notes

Reaction equation

HRID 649296 reaction equation
[CH:1]1([N:7]([CH3:36])[C:8](=[O:35])[CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([NH:23][C:24](=[O:26])[CH3:25])[N:17]([CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])[CH2:16]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:37]>C(OCC)(=O)C>[ClH:37].[CH:1]1([N:7]([CH3:36])[C:8](=[O:35])[CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([NH:23][C:24](=[O:26])[CH3:25])[N:17]([CH2:27][C:28]([OH:30])=[O:29])[CH2:16]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14181855HCID 14181855, compound

Product 1

HCID 20143507HCID 20143507, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of N-cyclohexyl-N-methyl-4-[2-acetamido-3-tert-butoxycarbonylmethyl-3,4-dihydroquinazolin-6-yl]oxybutyramide in ethyl acetate saturated with hydrogen chloride was stirred for 1 hour at room temperature. The resulting precipate was collected by filtration and dried to afford the title compound as a hygroscopic solid.

Workup

  1. filtrationThe resulting precipate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-c9dbb5493a554058acb2875e71d76211
Source dataset
uspto-grants-1988_04
Patent number
US04739056

Reaction notes

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