Ethyl Acetate → HCID 20143029, compound

HRID 649314Notes

Reaction equation

HRID 649314 reaction equation
Cl[C:2]1([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1.C(OCC)(=[O:23])C>O1CCCC1.O>[OH:23][C:2]1([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 20143033HCID 20143033, compound

Product 1

HCID 20143029HCID 20143029, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

2-Chloro-3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (0.1 g, compound No. 2) is dissolved in a mixture of tetrahydrofuran (2 ml) and water (1 ml), and the solution is standed overnight at room temperature. The mixture is poured into a mixture of ethyl acetate and water. The organic layer is dried over anhydrous sodium sulfate, and concentrated in vacuo to give 0.1 g (quant. yield) of the titled compound as amorphous powder.

Workup

  1. dry with materialThe organic layer is dried over anhydrous sodium sulfate
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8871e2aff44047229d70acd32d8a67a8
Source dataset
uspto-grants-1988_04
Patent number
US04739050

Reaction notes

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