Hydrochloric Acid → 1-Acetoxy-3-aminopropane hydrochloride

HRID 64933Notes

Reaction equation

HRID 64933 reaction equation
[C:1]([O:4][CH2:5][CH2:6][CH2:7][NH:8]C(OCC1C=CC=CC=1)=O)(=[O:3])[CH3:2].[ClH:19]>C(O)(C)C.[C].[Pd]>[ClH:19].[C:1]([O:4][CH2:5][CH2:6][CH2:7][NH2:8])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 202357821-Acetoxy-3-(benzyloxycarbonylamino)propane

Product 1

HCID 199308281-Acetoxy-3-aminopropane hydrochloride

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 3776IsopropanolSolvent

Procedure

In 200 ml of isopropanol was dissolved 28 g of the 1-acetoxy-3-(benzyloxycarbonylamino)propane, and 2.5 g of 5% palladium-carbon and 10 ml of conc. hydrochloric acid were added thereto, after which the resulting mixture was subjected to catalytic reduction at room temperature. Subsequently, the palladium-carbon was removed by filtration and the solvent was removed by distillation under reduced pressure to obtain 12 g of oily 1-acetoxy-3-aminopropane hydrochloride.

Workup

  1. additionwere added
  2. customwas subjected to catalytic reduction at room temperature
  3. customSubsequently, the palladium-carbon was removed by filtration
  4. customthe solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-0ea83086c8ea4f42b50c0df1d76b8c89
Source dataset
uspto-grants-1986_09
Patent number
US04610983

Reaction notes

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