Pyridine → HCID 14076561, compound

HRID 649430Notes

Reaction equation

HRID 649430 reaction equation
[C:1]([C:3]([CH2:13][CH3:14])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](Br)=[O:5])#[N:2].[CH2:15]([NH2:18])[CH2:16][CH3:17].N1C=CC=CC=1>C1C=CC=CC=1>[CH2:15]([NH:18][C:4](=[O:5])[C:3]([C:1]#[N:2])([CH2:13][CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:16][CH3:17]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7852PropylamineHCID 20141257HCID 20141257, compound

Product 1

HCID 14076561HCID 14076561, compoundYield 78.6%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

11 g of 2-cyano-2-ethyl-2-phenylacetyl bromide are added dropwise under cooling, at 20° to 30° C., to a solution of 3 g of n-propylamine and 4 g of pyridine in 20 ml of dry benzene. The reaction mixture is refluxed for 30 minutes and then processed as described in Example 3. 7.9 g (68.3%) of N-(n-propyl)-2-cyano-2-ethyl-2-phenylacetic acid amide are obtained; m.p.: 55°-56° C.

Workup

  1. temperatureThe reaction mixture is refluxed for 30 minutes

Sources & evidence

ORD record
ord-75563e0112314f91b2e5aa581822d94d
Source dataset
uspto-grants-1988_04
Patent number
US04740228

Reaction notes

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