Cyclohexylamine → HCID 14076563, compound

HRID 649433Notes

Reaction equation

HRID 649433 reaction equation
[C:1]([C:3]([CH3:13])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](Cl)=[O:5])#[N:2].[CH:14]1([NH2:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.C(N(CC)CC)C>CC(C)=O>[CH:14]1([NH:20][C:4](=[O:5])[C:3]([C:1]#[N:2])([CH3:13])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 7965CyclohexylamineHCID 8471TriethylamineHCID 12625034HCID 12625034, compound

Product 1

HCID 14076563HCID 14076563, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A solution of 9.75 g (0.05 mole) of 2-cyano-2-methyl-2-phenylacetyl chloride in 20 ml of acetone is cooled to 5° C., and a mixture of 5 g (0.05 mole) of cyclohexylamine, 5.2 g of triethyl amine and 10 ml of acetone is added to the solution under maintaining the temperature of the mixture below 10° C. The reaction mixture is poured into ice water, the separated solid is filtered off, and dried in vacuo. 12.12 g of N-cyclohexyl-2-cyano-2-methyl-2-phenylacetic acid amide are obtained; m.p.: 76°-78° C.

Workup

  1. additionis added to the solution
  2. temperatureunder maintaining the temperature of the mixture below 10° C
  3. filtrationthe separated solid is filtered off
  4. customdried in vacuo

Sources & evidence

ORD record
ord-aa00fa87ed2b417989e84057461cb37e
Source dataset
uspto-grants-1988_04
Patent number
US04740228

Reaction notes

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