Water → HCID 2798290, compound

HRID 649439Notes

Reaction equation

HRID 649439 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]([CH3:12])=O.Cl.[NH2:14][OH:15].C(=O)([O-])O.[Na+].O>CO>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10](=[N:14][OH:15])[CH3:12]

Participants

6

Reactant 4

HCID 962WaterHCID 154352-AcetylbenzofuranHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate

Product 1

HCID 2798290HCID 2798290, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Twenty six grams (g) (162 millimoles (mmol)) of commercially available 2-benzofuranylmethylketone was dissolved in 300 milliliters (ml) of methanol, and 16.9 g (243 mmol) of hydroxylamine hydrochloride and 20.4 g (243 mmol) of sodium hydrogencarbonate were added thereto. The resulting mixture was stirred at room temperature for 8 hours. Then, φml of water was added and the methanol was distilled away under reduced pressure. Precipitated crystals were filtered off and washed with water to yield 27.8 g of 2-benzofuranylmethylketone oxime having the following formula (yield, 98%). ##STR26##

Workup

  1. distillationthe methanol was distilled away under reduced pressure
  2. customPrecipitated crystals
  3. filtrationwere filtered off
  4. washwashed with water

Sources & evidence

ORD record
ord-f4337bd9fdf34739b4ee09b71ec4fbb4
Source dataset
uspto-grants-1988_04
Patent number
US04740230

Reaction notes

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