Sodium Iodide → HCID 13934595, compound

HRID 649562Notes

Reaction equation

HRID 649562 reaction equation
[C:1]1([N:7]2[C:16]3[N:15]=[CH:14][CH:13]=[CH:12][C:11]=3[C:10]3[O:17][CH2:18][CH2:19][C:9]=3[C:8]2=[S:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I-].[Na+]>CC(N(C)C)=O>[C:1]1([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][N:15]=3)[C:10](=[O:17])[C:9]3[CH2:19][CH2:18][S:20][C:8]2=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 13934592HCID 13934592, compound

Product 1

HCID 13934595HCID 13934595, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of 3,5-dihydro-5-phenyl-furo-[3,2-c]-[1,8]naphthyridin-4(2H)-thione (500 mg.) and sodium iodide (500 mg.) in dry dimethylacetamide (5 ml.) was stirred in an atmosphere of nitrogen and heated at 125° for 2 hr. After cooling, the solution was poured into ice-water, filtered, washed with water and dried to yield the desired product, m.p. 260°-261° C.

Workup

  1. temperatureheated at 125° for 2 hr
  2. temperatureAfter cooling
  3. filtrationfiltered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-136870a2195448eda09d35ed58982ae1
Source dataset
uspto-grants-1988_04
Patent number
US04740511

Reaction notes

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