Potassium Carbonate → HCID 18003869, compound

HRID 649711Notes

Reaction equation

HRID 649711 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.C(=O)([O-])[O-].[K+].[K+].F[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:18]=1[CH3:26]>O>[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:18]=2[CH3:26])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 787361H-Imidazole-1-propanamine

Product 1

HCID 18003869HCID 18003869, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 250.4 g (2 mol) of 3-imidazol-1-ylpropylamine and 82.8 g (0.6 mol) of potassium carbonate in 280 ml of water was heated to 90° C. 155.1 g (1 mol) of 1-fluoro-2-methyl-4-nitrobenzene were added dropwise over 30 minutes and the mixture was maintained at a temperature of 90-95° C. for 4 hours.

Workup

  1. temperaturethe mixture was maintained at a temperature of 90-95° C. for 4 hours

Sources & evidence

ORD record
ord-2c81e43639a8439d891969d2711a07e8
Source dataset
uspto-grants-2001_08
Patent number
US06270533B1

Reaction notes

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