反应详情

A mixture of 0.3 g of Compound 1B, 0.2 mL of 1-benzylpiperazine, 0.14 mL of acetic acid, 0.38 g of sodium triacetoxyborohydride and 7 mL of methylene chloride was stirred at room temperature for 24 h. Afterwards, it was diluted with water, alkalinized with 5% aq. sodium hydrogencarbonate. The organic layer was separated, dried on sodium sulphate and evaporated to dryness in vacuo affording a crude, which was purified by flash chromatography (methylene chloride—methanol 9.5:0.5) affording 0.03 g (3.6% overall from Compound 1A) of the title product.

1. customThe organic layer was separated
2. customdried on sodium sulphate
3. customevaporated to dryness in vacuo
4. customaffording a crude, which
5. customwas purified by flash chromatography (methylene chloride—methanol 9.5:0.5)