Anisole → HCID 18422187, compound

HRID 649940Notes

Reaction equation

HRID 649940 reaction equation
[NH2:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[NH:4][C:5]1[S:9][C:8]2[CH:10]=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:7]=2[C:6]=1[C:16](OCC)=O.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.C1(OC)C=CC=CC=1>[Ti](Cl)(Cl)(Cl)Cl>[F:25][C:22]1[CH:23]=[CH:24][C:2]2[N:1]=[C:16]([N:30]3[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]3)[C:6]3[C:7]4[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:8]=4[S:9][C:5]=3[NH:4][C:3]=2[CH:21]=1

Participants

5

Reactant 3

HCID 7519AnisoleHCID 531671-MethylpiperazineHCID 18422282HCID 18422282, compound

Product 1

HCID 18422187HCID 18422187, compound

Reagents, catalysts & solvents 1

HCID 24193Titanium TetrachlorideCatalyst

Procedure

In the same manner as in Example 1 and using ethyl 2-(2-amino-5-fluoroanilino)-6-methoxybenzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 8-fluoro-3-methoxy-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.

Sources & evidence

ORD record
ord-c5e167f6d2174afeb0bfe6a61f950afa
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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