反应详情

A solution of 2.55 g of N-tert-butyloxycarbonyl-(2S)-2-(4-trifluoromethylphenylthiomethyl)-pyrrolidine in 5.64 ml of trifluoroacetic acid is stirred for 1 hour at 0° C. and then for 3.5 hours at room temperature. The reaction mixture is poured onto 10% sodium bicarbonate solution, extracted with ethyl acetate, washed twice with 2 M hydrochloric acid, the water phase is extracted with ether, made basic with sodium bicarbonate, extracted three times with ethyl acetate, washed with common salt solution, dried on sodium sulfate and concentrated by evaporation. 557 mg of (2S)-2-(4-trifluoromethylphenylthio-methyl)-pyrrolidine is obtained.

1. extractionextracted with ethyl acetate
2. washwashed twice with 2 M hydrochloric acid
3. extractionthe water phase is extracted with ether
4. extractionextracted three times with ethyl acetate
5. washwashed with common salt solution
6. customdried on sodium sulfate
7. concentrationconcentrated by evaporation