HRID650427

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID784

Hydrogen peroxide

H2O2

HCID6386

tert-Butyl alcohol

C4H10O

HCID24437

Sodium sulfite

Na2O3S

结构：CC1(C)CC(OC(=O)CCC(=O)OC2CC(C)(C)N(O)C(C)(C)C2)CC(C)(C)N1O

HCID326921

Bis(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) butanedioate

C22H40N2O6

PRODUCTS

生成物

结构：CC(C)(O)CON1C(C)(C)CC(OC(=O)CCC(=O)OC2CC(C)(C)N(OCC(C)(C)O)C(C)(C)C2)CC1(C)C

HCID54162330

未命名化合物

PROCEDURE

实验过程

Aqueous hydrogen peroxide is added to a mixture of bis(1-oxyl-2,2,6,6-tetramethylpieridin-4-yl) succinate and ferrous chloride tetrahydrate in tert-butyl alcohol at 30-50° C. Excess peroxide is decomposed with aqueous sodium sulfite solution. The organic layer is concentrated and the crude product is purified by flash chromatography on silica gel to afford the title compound.

WORKUP

后处理

concentrationThe organic layer is concentrated
customthe crude product is purified by flash chromatography on silica gel

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d2f8a3e38f5d4fdc81541ce3ae6931d0
来源数据集: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06271377B1
来源说明: uspto-grants-2001_08

反应 SMILES

OO.[C:3]([O:21][CH:22]1[CH2:27][C:26]([CH3:29])([CH3:28])[N:25]([OH:30])[C:24]([CH3:32])([CH3:31])[CH2:23]1)(=[O:20])[CH2:4][CH2:5][C:6]([O:8][CH:9]1[CH2:14][C:13]([CH3:16])([CH3:15])[N:12]([OH:17])[C:11]([CH3:19])([CH3:18])[CH2:10]1)=[O:7].S([O-])([O-])=O.[Na+].[Na+].[C:39]([OH:43])([CH3:42])([CH3:41])[CH3:40]>>[OH:43][C:39]([CH3:42])([CH3:41])[CH2:40][O:17][N:12]1[C:13]([CH3:16])([CH3:15])[CH2:14][CH:9]([O:8][C:6](=[O:7])[CH2:5][CH2:4][C:3]([O:21][CH:22]2[CH2:27][C:26]([CH3:29])([CH3:28])[N:25]([O:30][CH2:40][C:39]([OH:43])([CH3:42])[CH3:41])[C:24]([CH3:32])([CH3:31])[CH2:23]2)=[O:20])[CH2:10][C:11]1([CH3:19])[CH3:18]