N-(2,4-Dimethylthiophen-3-yl)-N-n-propylcarbamoyl chloride → N-(2,4-Dimethylthiophen-3-yl)-N-n-propyl-4,5-dihydro-4-(2-fluoro-phenyl)-1H-tetrazol-5-one-1-carboxamide

HRID 650871Notes

Reaction equation

HRID 650871 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12](=[O:13])[N:11]=[N:10][NH:9]1.[CH3:14][C:15]1[S:16][CH:17]=[C:18]([CH3:27])[C:19]=1[N:20]([CH2:24][CH2:25][CH3:26])[C:21](Cl)=[O:22]>CN(C)C1C=CN=CC=1>[CH3:14][C:15]1[S:16][CH:17]=[C:18]([CH3:27])[C:19]=1[N:20]([CH2:24][CH2:25][CH3:26])[C:21]([N:11]1[C:12](=[O:13])[N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[N:9]=[N:10]1)=[O:22]

Participants

4

Reactant 2

HCID 53969524N-(2,4-Dimethylthiophen-3-yl)-N-n-propylcarbamoyl chlorideHCID 178518973HCID 178518973, compound

Product 1

HCID 21709943N-(2,4-Dimethylthiophen-3-yl)-N-n-propyl-4,5-dihydro-4-(2-fluoro-phenyl)-1H-tetrazol-5-one-1-carboxamide

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

1.17 g (6.5 mmol) of 1,2-dihydro-1-(2-fluorophenyl)-5H-tetrazol-5-one, 1.5 g (6.5 mmol) of N-(2,4-dimethyl-thiophen-3-yl)-N-n-propylcarbamoyl chloride and 1.19 g (9.7 mmol) of 4-dimethylaminopyridine were reacted by the method of the process described in Example 1. Yield 1.9 g.

Sources & evidence

ORD record
ord-38041aabf37b4880a244b1a4c13767e3
Source dataset
uspto-grants-2001_08
Patent number
US06277790B1

Reaction notes

Loading…