N-Propyl-N-(tetrahydrofuran-3-yl)carbamoyl chloride → N-Propyl-N-(tetrahydrofuran-3-yl)-4,5-dihydro-4-(2-fluorophenyl)-1H-tetrazol-5-one-1-carboxamide

HRID 650875Notes

Reaction equation

HRID 650875 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12](=[O:13])[N:11]=[N:10][NH:9]1.[CH2:14]([N:17]([CH:21]1[CH2:25][CH2:24][O:23][CH2:22]1)[C:18](Cl)=[O:19])[CH2:15][CH3:16]>CN(C)C1C=CN=CC=1>[CH2:14]([N:17]([CH:21]1[CH2:25][CH2:24][O:23][CH2:22]1)[C:18]([N:11]1[C:12](=[O:13])[N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[N:9]=[N:10]1)=[O:19])[CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 21709911N-Propyl-N-(tetrahydrofuran-3-yl)carbamoyl chlorideHCID 178518973HCID 178518973, compound

Product 1

HCID 21709940N-Propyl-N-(tetrahydrofuran-3-yl)-4,5-dihydro-4-(2-fluorophenyl)-1H-tetrazol-5-one-1-carboxamide

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

1.4 g (7.8 mmol) of 1,2-dihydro-1-(2-fluorophenyl)-5H-tetrazol-5-one, 1.5 g (7.8 mmol) of N-propyl-N-(tetrahydro-furan-3-yl)carbamoyl chloride and 1.29 g (10 mmol) of 4-dimethylaminopyridine were reacted by the method of the process described in Example 1. Yield 2.1 g.

Sources & evidence

ORD record
ord-92c9e84815214661af094841c5484a7c
Source dataset
uspto-grants-2001_08
Patent number
US06277790B1

Reaction notes

Loading…