反应详情

Compound 5A (826 mg; 2.49 mmol) in solution in toluene (20 ml) is treated, at room temperature, with trifluoroacetic acid (2.75 ml). After 1 h, the medium is evaporated to dryness and coevaporated 3 times with toluene. The product obtained is taken up in methanol (20 ml) and triethylamine (8 ml), stirred for 15 min at room temperature and finally evaporated to dryness. The solid obtained is purified by chromatography on a silica gel column eluted with a dichloro-methane/methanol/ammonium hydroxide mixture in the proportions 90/9/1 to give the intermediate 5B.

1. customthe medium is evaporated to dryness
2. customThe product obtained
3. customfinally evaporated to dryness
4. customThe solid obtained
5. customis purified by chromatography on a silica gel column
6. washeluted with a dichloro-methane/methanol/ammonium hydroxide mixture in the proportions 90/9/1