反应详情

温度

25 °C

1N NaOH (35 ml) was added to a suspension of [(5-chloro-1H-indole-2-carbonyl)-amino]-acetic acid methyl ester (8.0 g, 30 mmol) in THF (100 ml) and the resulting mixture stirred for 18 hours at 25° C. The solution was acidified with 6N HCl (7 mL), the mixture concentrated, the solids suspended in water, filtered, and washed with water (7.42 g, 98%): HPLC (60/40) 2.89 minutes (100 %;)

1. concentrationthe mixture concentrated
2. filtrationfiltered
3. washwashed with water (7.42 g, 98%)
4. custom(60/40) 2.89 minutes (100 %;)