Pyridine → HCID 22465461, compound

HRID 651228Notes

Reaction equation

HRID 651228 reaction equation
[C:1]1([NH:7][C:8](=O)[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.P(Cl)(Cl)([Cl:20])=O>ClCCl>[C:1]1([N:7]=[C:8]([Cl:20])[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 121072-MethylacetanilideHCID 24813Phosphorus oxychloride

Product 1

HCID 22465461HCID 22465461, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

N-phenylpropionamide(149.2 g, 1.0 mol) and pyridine(261.0 g, 3.3 mol) were dissolved in dichloromethane(300 g), and the mixture was cooled to 0° C. Phosphorus oxychloride(168.7 g, 1.1 mol) was added dropwise thereto for 2 hours, and then the mixture was stirred at room temperature (20° C.) for 2 hours to produce N-phenylpropionimidoylchloride.

Sources & evidence

ORD record
ord-356303691e63401ea120afc8bd3fb6eb
Source dataset
uspto-grants-2001_08
Patent number
US06277995B1

Reaction notes

Loading…