反应详情

温度

0 °C

N-phenylpropionamide(149.2 g, 1.0 mol) and pyridine(261.0 g, 3.3 mol) were dissolved in dichloromethane(300 g), and the mixture was cooled to 0° C. Phosphorus oxychloride(168.7 g, 1.1 mol) was added dropwise thereto for 2 hours, and then the mixture was stirred at room temperature (20° C.) for 2 hours to produce N-phenylpropionimidoylchloride.