反应详情

温度

80 °C

A mixture of ethyl 2-azidoacetate (1.29 g) and 2-chloroacrylonitrile (1.75 g) in water (10 ml) is stirred at about 80° C. for 16 hours. After cooling, the product is extracted with dichloromethane and the concentrated extract is purified by means of column chromatography on silica gel 60 (6 g; eluent toluenelethyl acetate=4:1). The purified product (yield 1.21 g; 67% of theory) of m.p. 47-48° C. (recrystallization from toluene/hexane) is obtained after concentrating the eluate and drying.

1. temperatureAfter cooling
2. extractionthe product is extracted with dichloromethane
3. extractionthe concentrated extract
4. customis purified by means of column chromatography on silica gel 60 (6 g; eluent toluenelethyl acetate=4:1)
5. customThe purified product (yield 1.21 g; 67% of theory) of m.p. 47-48° C. (recrystallization from toluene/hexane)
6. customis obtained
7. concentrationafter concentrating the eluate and
8. customdrying