Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride

HRID 651287Notes

Reaction equation

HRID 651287 reaction equation
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7])#[N:2].C(Cl)(=O)C([Cl:18])=O>CN(C)C=O.C(Cl)Cl>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:18])=[O:7])#[N:2]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 18417533195532-64-0

Product 1

HCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

111 g of 3-cyano-2,4,5-trifluoro-benzoic acid, 84 g of oxalyl chloride and a few drops of dimethylformamide in 930 ml of dry methylene chloride are stirred at room temperature for 5 hours. The reaction mixture is concentrated by evaporation and the residue is distilled in vacuo.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. distillationthe residue is distilled in vacuo

Sources & evidence

ORD record
ord-1abbf27288ca486b9d54f2bbfd337b1c
Source dataset
uspto-grants-2001_08
Patent number
US06278013B1

Reaction notes

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