反应详情

A mixture of 4-cyano-4′-hydroxybiphenyl (56) (10.10 g, 0.052 mol), 1-bromodecane (14.38 g, 0.065 mol), anhydrous potassium carbonate (37.32 g, 0.27 mol), butanone (300 ml) and a trace of potassium iodide was heated under reflux overnight. The cooled solution was filtered to remove inorganic salts and the solvent was removed in vacuo. The residual oil was distilled (to remove excess bromide) and finally purified by column chromatography (dichloromethane) to yield a colourless, low melting solid.

1. temperatureunder reflux overnight
2. filtrationThe cooled solution was filtered
3. customto remove inorganic salts
4. customthe solvent was removed in vacuo
5. distillationThe residual oil was distilled
6. custom(to remove excess bromide)
7. customfinally purified by column chromatography (dichloromethane)
8. customto yield a colourless,