反应详情

温度

0 °C

To a solution of [1-(1-chloro-isoquinolin-7-ylmethyl)-2-oxopyrrolidin-3(S)-yl]-carbamic acid tert-butyl ester (2.1 g, 5.6 mmol) in EtOAc (170 mL) at 0° C. is bubbled HCl gas for 5 minutes. The solution is stirred at 0° C. for 15 minutes, then the ice bath is removed and the solution allowed to warn to room temperature. After 4 hours at room temperature, the solution is concentrated and the remaining solid is washed with ether to give the title compound (1.74 g, 5.6 mmol) as a pale yellow solid.

1. customthe ice bath is removed
2. customto warn to room temperature
3. waitAfter 4 hours at room temperature
4. concentrationthe solution is concentrated
5. washthe remaining solid is washed with ether