反应详情

Benzaldehyde(8.9 g, 84 mmol) is added to a suspension of 2-amino-4-methylbenzonitrile (10.0 g, 76 mmol) in heptane (250 mL), and the mixture refluxed under nitrogen overnight. The hot solution is decanted into a pre-warmed flask to leave the insoluble brown oil material behind, and the solution cooled to room temperature after adding ethyl acetate (2 mL). The resulting solid is filtered off and washed with heptane:ethyl acetate=100:1 (2×25 mL), and dried under high vacuum to give a beige powder (12.54 g, 57 mmol).

1. temperaturethe mixture refluxed under nitrogen overnight
2. customThe hot solution is decanted into a pre-warmed flask
3. customto leave the insoluble brown oil material behind, and the solution
4. filtrationThe resulting solid is filtered off
5. washwashed with heptane
6. dry with materialethyl acetate=100:1 (2×25 mL), and dried under high vacuum