反应详情

A solution of 11.4 g (0.1 mole) of 2-chloropyrimidine and 23.2 g (0.1 mole) of 1-(6-benzodioxinyl methyl)piperazine (oil) in 500 ml of pentanol, as refluxed for 6 hours, in the presence of 13.8 g (0.1 mole) of potassium carbonate. After the completion of the reaction, the so-formed salt was filtered off and the solvent was evaporated under reduced pressure. The so-obtained oily residue (30 g) was dissolved in 160 ml of anhydrous ethanol. After addition of an excess of hydrochloric acid ether solution, the dihydrochloride crystallises. 30 g of 1-(benzodioxin-6-yl methyl)-4-(pyrimidin-2-yl)piperazine dihydrochloride white crystals were finally obtained, melting at 215°-220° C.

1. customAfter the completion of the reaction
2. filtrationthe so-formed salt was filtered off
3. customthe solvent was evaporated under reduced pressure
4. dissolutionThe so-obtained oily residue (30 g) was dissolved in 160 ml of anhydrous ethanol
5. additionAfter addition of an excess of hydrochloric acid ether solution
6. customthe dihydrochloride crystallises