Allylamine → HCID 13747166, compound

HRID 651963Notes

Reaction equation

HRID 651963 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12.[CH2:12]([NH2:15])[CH:13]=[CH2:14]>O>[CH2:12]([NH:15][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12)[CH:13]=[CH2:14]

Participants

4

Reactant 2

HCID 7853AllylamineHCID 116798717-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine

Product 1

HCID 13747166HCID 13747166, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (1.0 g, 0.006 mole) and allylamine (60 g) in water (100 ml) was heated under reflux for 12 days. On cooling the reaction mixture was evaporated to dryness, basified to pH8 with 10% sodium carbonate solution and the resulting solid filtered off. Recrystallisation from chloroform/pentane gave the product as white solid (1.0 g). m.p. 172°-174° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 12 days
  3. temperatureOn cooling the reaction mixture
  4. customwas evaporated to dryness
  5. filtrationthe resulting solid filtered off
  6. customRecrystallisation from chloroform/pentane

Sources & evidence

ORD record
ord-8ceafe762bf746c1b5531cc156e2df43
Source dataset
uspto-grants-1987_06
Patent number
US04670432

Reaction notes

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