反应详情

7-Chloro-5-methyl-H-pyrazolo[4,3-b]pyridine (D4) (0.5 g, 0.003 mole) and 3-aminopropanol (0.75 g, 0.01 mole) in dry xylene (5 ml) were heated under reflux for 4 h. The solvent was removed under reduced pressure and the resulting oil recrystallised from methanol/ethyl acetate to give the hydrochloride salt of the title compound as a white crystalline solid (398 mg, 55%), m.p. 194°-196° C.

1. temperatureunder reflux for 4 h
2. customThe solvent was removed under reduced pressure
3. customthe resulting oil recrystallised from methanol/ethyl acetate