Hydrogen Peroxide → HCID 178493598, compound

HRID 651986Notes

Reaction equation

HRID 651986 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:5][C:4]=1[C:14]1[NH:15][C:16]2[C:17]([N:22]=1)=[N:18][CH:19]=[CH:20][CH:21]=2.[OH:23]O>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:5][C:4]=1[C:14]1[NH:15][C:16]2[C:17]([N:22]=1)=[N+:18]([O-:23])[CH:19]=[CH:20][CH:21]=2

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 13282053Phenol, 4-(1H-imidazo(4,5-b)pyridin-2-yl)-3-methoxy-, methanesulfonate (ester)

Product 1

HCID 178493598HCID 178493598, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3.19 g of 2-(2-methoxy-4-methanesulfonyloxy-phenyl)imidazo[4,5-b]pyridine were dissolved in 25 ml of trifluoroacetic acid, and then 5 ml of 30% hydrogen peroxide were added dropwise thereto. The mixture was refluxed for one hour and concentrated to about one-tenth of its volume. The residue was poured onto ice and digested until it had crystallized throughout.

Workup

  1. temperatureThe mixture was refluxed for one hour
  2. concentrationconcentrated to about one-tenth of its volume
  3. additionThe residue was poured onto ice
  4. customhad crystallized throughout

Sources & evidence

ORD record
ord-0714026285204a8da717b517e8076571
Source dataset
uspto-grants-1987_06
Patent number
US04670438

Reaction notes

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