Hydrochloric Acid → HCID 135626360, compound

HRID 652000Notes

Reaction equation

HRID 652000 reaction equation
[CH:1]1([N:7]([CH2:29][CH2:30][O:31]C(=O)C)[C:8](=[O:28])[CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]2[NH:23][C:24](=[O:27])[C:25](=[CH2:26])[N:17]2[CH2:16]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].Cl>C(O)C>[CH:1]1([N:7]([CH2:29][CH2:30][OH:31])[C:8](=[O:28])[CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]2[NH:23][C:24](=[O:27])[C:25](=[CH2:26])[N:17]2[CH2:16]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 135626364HCID 135626364, compound

Product 1

HCID 135626360HCID 135626360, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N-cyclohexyl-N-(2-acetoxyethyl)-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutanamide 50 mg in ethanol (20 ml) was added 3N NaOH (5 ml) in small portions. After 30 minutes at room temperature, the reaction mixture was neutralized with concentrated HCl and the resulting precipitate was collected by filtration and dried to give the title compound.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-ceb7fe28475348d2a651bc4c8f519518
Source dataset
uspto-grants-1987_06
Patent number
US04670434

Reaction notes

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