Piperidin-4-ol → 6-(2-Chlorophenyl)-3-(4-hydroxypiperidino)-1,2,4-triazine

HRID 65202Notes

Reaction equation

HRID 65202 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])=[CH:6][N:7]=1.[OH:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(O)C>[Cl:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:5]1[N:4]=[N:3][C:2]([N:19]2[CH2:20][CH2:21][CH:16]([OH:15])[CH2:17][CH2:18]2)=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 79341Piperidin-4-olHCID 125812883-Chloro-6-(o-chlorophenyl)-1,2,4-triazine

Product 1

HCID 136055266-(2-Chlorophenyl)-3-(4-hydroxypiperidino)-1,2,4-triazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7.4 g of 3-chloro-6-(2-chlorophenyl)-1,2,4-triazine, prepared according to J. Het. Chem. 16, 1402 (1979), and 9 g of 4-hydroxypiperidine are heated under reflux in 150 ml of ethanol for 3 hours.

Sources & evidence

ORD record
ord-9445a3bf9c0f4684960d69b700f0cd72
Source dataset
uspto-grants-1986_09
Patent number
US04613603

Reaction notes

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