反应详情

A mixture of 17.1 g of benzyl bromide, 13.6 g of 4-hydroxyacetophenone, 27.6 g of potassium carbonate and 200 ml of acetone was refluxed for 7 hours, then cooled and filtered. The filtrate was concentrated, then distilled on a Kugelrohr at 130°-140° C., 0.1 mm Hg. The oil was dissolved in acetone and then concentrated, giving the desired intermediate as a white solid, mp 92°-93° C.

1. temperaturewas refluxed for 7 hours
2. temperaturecooled
3. filtrationfiltered
4. concentrationThe filtrate was concentrated
5. distillationdistilled on a Kugelrohr at 130°-140° C.
6. dissolutionThe oil was dissolved in acetone
7. concentrationconcentrated