反应详情

A mixture of 2.55 g of 1-(2-phenyl-4-quinolyl)-2-(4-piperidyl)-ethanol (racemic), 1.1 g of methyl iodide and 0.6 g of potassium carbonate in 20 ml of dimethylformamide was stirred for 2 hours at the ambient temperature. 20 ml of water and 30 ml of toluene were then added. The organic phase was separated, wahsed with water, dried over magnesium sulfate and evaporated under reduced pressure. 1 g of crude product was obtained which was fixed on a column of silica gel. The elution was effected with a 9/1 chloroform-diethylamine mixture. 0.57 g of 2-(1-methyl-4-piperidyl)-1-(2-phenyl-4-quinolyl)-ethanol (racemic), which melted at 208° C. was thus isolated.

1. customThe organic phase was separated
2. dry with materialdried over magnesium sulfate
3. customevaporated under reduced pressure
4. custom1 g of crude product was obtained which
5. washThe elution