Water → HCID 53995785, compound

HRID 652266Notes

Reaction equation

HRID 652266 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Na+].[CH2:19](I)[CH3:20].O>CN(C)C=O>[CH2:19]([O:10][C:9](=[O:11])[CH2:8][C:6]1[CH:5]=[CH:4][C:3]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[C:2]([NH2:1])[CH:7]=1)[CH3:20]

Participants

5

Reactant 3

HCID 962WaterHCID 6340IodoethaneHCID 23702197HCID 23702197, compound

Product 1

HCID 53995785HCID 53995785, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Sodium 2-amino-4-biphenylacetate is dissolved in dimethylformamide and the solution treated with ethyliodide. The solution is stirred at room temperature for about 3 hours, the solution added to water and the mixture extracted several times with benzene. The combined benzene extracts are washed with dilute base and water, dried over sodium sulfate, concentrated and crystallized to give ethyl-2-amino-4-biphenylacetate.

Workup

  1. extractionthe mixture extracted several times with benzene
  2. washThe combined benzene extracts are washed
  3. additionwith dilute base and water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated
  6. customcrystallized

Sources & evidence

ORD record
ord-9aac6ea2b10d42bc8351e326e5c80e73
Source dataset
uspto-grants-1987_06
Patent number
US04670566

Reaction notes

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