Ethyl formate → HCID 12803197, compound

HRID 652445Notes

Reaction equation

HRID 652445 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH:14][C:15](=[O:24])[O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[CH:25](OCC)=[O:26]>C(O)C>[CH:25]([NH:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH:14][C:15](=[O:24])[O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:26]

Participants

4

Reactant 2

HCID 8025Ethyl formateHCID 12803194HCID 12803194, compound

Product 1

HCID 12803197HCID 12803197, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of phenylmethyl [2-[5-(aminomethyl)-1H-indol-3-yl]ethyl]carbamate (0.25 g), ethyl formate (5 ml) and ethanol (1 ml) was heated under reflux for 9 h. The solvent was evaporated in vacuo and the residue was evaporated with ethanol (2×5 ml) to give the title compound (0.27 g) as cream crystals m.p. 114°-6°.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 9 h
  3. customThe solvent was evaporated in vacuo
  4. customthe residue was evaporated with ethanol (2×5 ml)

Sources & evidence

ORD record
ord-7a92483a4bc642d295f856d442038cfa
Source dataset
uspto-grants-1987_06
Patent number
US04672067

Reaction notes

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