Methyl 2-(bromomethyl)benzoate → Methyl Benzoate

HRID 652519Notes

Reaction equation

HRID 652519 reaction equation
OC1C(CCC)=C(O)C=CC=1C(=O)C.BrC[C:17]1[CH:26]=[CH:25][CH:24]=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]>>[CH3:22][O:21][C:19](=[O:20])[C:18]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:17]=1

Participants

3

Reactant 2

HCID 2734813Methyl 2-(bromomethyl)benzoateHCID 27751982',4'-Dihydroxy-3'-propylacetophenone

Product 1

HCID 7150Methyl Benzoate

Procedure

1-(2,4-dihydroxy-3-propylphenyl)ethanone was allowed to react with methyl 2-bromomethylbenzoate according to the procedure of Example 69 and the product was purified by recrystallization from hexane to give 2-[4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid methyl ester, the title compound, m.p. 90°-93°, in 78% yield. Analysis Calculated for C20H22O5 : C, 70.16, H, 6.48. Found: C, 69.97; H, 6.36.

Workup

  1. customthe product was purified by recrystallization from hexane

Sources & evidence

ORD record
ord-4a6426ca68844ec58f249ac671688d4d
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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