反应详情

A mixture of 4.3 g of 2-(4-hydroxyphenyl)ethylacetoacetate (10), 2.3 g of methyl β-amino-crotonate, 2.9 g of 3-nitrobenzaldehyde and 70 mL of methanol was heated at reflux for 12 hours. The solvent was removed under reduced pressure and the residue purified by silica gel chromatography using 50:50 ethyl acetate-hexane to yield 5.9 g of 2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-[2-(4-hydroxyphenyl)ethoxycarbonyl]-1,4-dihydropyridine (11), as an amorphous solid.

1. temperaturewas heated
2. temperatureat reflux for 12 hours
3. customThe solvent was removed under reduced pressure
4. customthe residue purified by silica gel chromatography