Ammonium Hydroxide → HCID 20197534, compound

HRID 652552Notes

Reaction equation

HRID 652552 reaction equation
Cl.[CH3:2][C:3]1[NH:4][C:5]([CH3:39])=[C:6]([C:22]([O:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([NH:33][CH2:34][C:35]([O:37][CH3:38])=[O:36])=[CH:29][CH:28]=2)=[O:23])[CH:7]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:8]=1[C:9]([O:11][CH3:12])=[O:10].[NH4+].[OH-]>O>[CH3:2][C:3]1[NH:4][C:5]([CH3:39])=[C:6]([C:22]([O:24][CH2:25][CH2:26][C:27]2[CH:28]=[CH:29][C:30]([NH:33][CH2:34][C:35]([O:37][CH3:38])=[O:36])=[CH:31][CH:32]=2)=[O:23])[CH:7]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:8]=1[C:9]([O:11][CH3:12])=[O:10]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 20197533HCID 20197533, compound

Product 1

HCID 20197534HCID 20197534, compoundYield 91.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3.5 g of 2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-[2-(4-methoxycarbonylmethylaminophenyl)ethoxycarbonyl]-1,4-dihydropyridine hydrochloride salt in water (50 mL) is adjusted to pH 12 with NH4OH solution and extracted with methylene chloride. The methylene chloride is then evaporated to afford 3 g of 2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-[2-(4-methoxycarbonylmethylaminophenyl)ethoxycarbonyl]-1,4-dihydropyridine as the free base.

Workup

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride is then evaporated

Sources & evidence

ORD record
ord-1aa3661ab0d14edbaa8c9d0e42805de6
Source dataset
uspto-grants-1987_06
Patent number
US04672071

Reaction notes

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