反应详情

To a solution of 71 mg of potassium hydroxide in 6 ml of ethanol were added 253 mg of α-mercaptomethyl-β-(p-nitrophenyl)-γ-butyrolactone and 239 mg of benzyl bromide and the resulting mixture was kept at room temperature for 4 hours. After completion of the reaction, the reaction mixture was diluted with 60 ml of ethyl acetate, washed with water and saturated saline, dried over magnesium sulfate and the solvent was distilled off. The resulting crude product was purified by a silica gel column chromatography to give 218 mg (yield 50%) of the title compound.

1. customAfter completion of the reaction
2. washwashed with water and saturated saline
3. dry with materialdried over magnesium sulfate
4. distillationthe solvent was distilled off
5. customThe resulting crude product was purified by a silica gel column chromatography