Methane → epsilon(4-Amino 2-methoxy-benzenesulfonamido)caproic acid

HRID 65271Notes

Reaction equation

HRID 65271 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:12])=[O:11])=[C:6]([O:22][CH3:23])[CH:5]=1)([O-])=O.C>C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:11])=[O:12])=[C:6]([O:22][CH3:23])[CH:5]=1

Participants

4

Reactant 2

HCID 297MethaneHCID 13192117epsilon(4-Nitro 2-methoxy-benzenesulfonamido)caproic acid

Product 1

HCID 13192164epsilon(4-Amino 2-methoxy-benzenesulfonamido)caproic acidYield 98%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of ε(4-nitro 2-methoxy-benzenesulfonamido)caproic acid (1.4 g) in solution in ethyl acetate (150 cm3) is stirred magnetically under a hydrogen atmosphere in the presence of 5% palladized charcoal (120 mg). After four hours, the hydrogen absorption being terminated, the catalyst is filtered and the filtrate concentrated under reduced pressure. Pure ε(4-amino 2-methoxy-benzenesulfonamido)caproic acid is obtained, with a yield of 98%.

Workup

  1. customthe hydrogen absorption
  2. custombeing terminated
  3. filtrationthe catalyst is filtered
  4. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-0798acd525f64795904670e72a5587f5
Source dataset
uspto-grants-1986_09
Patent number
US04613618

Reaction notes

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